Jagged, always funny and fitfully hilarious, “We’re the Millers” is a comedy that will make grownups laugh out loud — maybe not as hard or as often as they did in “The Heat,” but certainly enough to leave them smiling when they depart the theater.

The setup is uncomplicated: David (Jason Sudeikis, “Horrible Bosses”) is a drug dealer, a vocation he has pursued since college. He’s unattached, fairly content and lazy.

One night, he tries to help his teenage neighbor Kenny (Will Poulter, in a scene-stealing role) when a group of thugs try to take the cellphone of a homeless girl named Casey (Emma Roberts). Kenny, whose mother has pretty much abandoned him, is lonely, and doesn't know when to stop talking. Kenny, in fact, talks so much that the criminals end up taking a stash of money from David.

Now David is in a fix: That was the money he owed his supplier (Ed Helms), who concocts a way for David to pay him back. All David has to do is drive to Mexico to pick up a “smidge” of marijuana and then bring it back across the border. David is promised $100,000 if he successfully completes his assignment by the deadline.

David comes up with the idea of asking three other people to pose as his family so he doesn't arouse suspicion while crossing the border. So, he convinces his neighbor, Rose (Jennifer Aniston), to pose as his wife. Casey and Kenny complete the not-so-happy “family,” and off they go in their recreational vehicle. 

The funniest parts of the film involve the "family’s" challenge to appear “normal.” There’s a clever scene aboard an airplane when the suspicions of a flight attendant are laid to rest by a sudden family “prayer meeting.” Each character takes a turn at explaining their plight or weaseling out of situations.

Even though they survive the border crossing, the four have no idea that the real danger lies ahead. A vicious drug cartel isn’t the only problem: Nick Offerman and Kathryn Hahn play an annoying couple who want to get chummy with the Miller troupe. 

Each character is good for several hearty laughs, and one of the tertiary characters is particularly amusing. Casey, who has questionable taste in boyfriends, picks up the dunderheaded Scottie P. (the wonderful Mark L. Young) along the way. His scenes with her “parents” are outrageously comical.

You won’t want to take your whole family, but grownups who enjoy raunchy comedy will have a great time with the Millers.