CLEVELAND — The Cleveland Indians can return to clinching their division and playoff preparations.

Their historic winning streak is, well, history.

Cleveland had its AL record run stopped at 22 straight games on Friday night as the Indians were beaten 4-3 by the Kansas City Royals, who became the first team to conquer the defending league champions since Aug. 23.

Jason Vargas (16-10) pitched into the sixth and Brandon Moss homered off Trevor Bauer (16-9) as the Royals ended baseball's longest win streak in 101 years. The Indians set a new league mark and came within four of matching the overall record held by the 1916 New York Giants.

Following a magical, walk-off win in extra innings on Thursday night, the Indians couldn't muster another late rally and fell for the first time in more than three weeks.

When Francisco Lindor struck out with a runner on first to end it, the packed crowd gave the Indians a prolonged standing ovation. Manager Terry Francona and the Cleveland players came out of the dugout to salute their fans.

Cubs 8, Cardinals 2: Kris Bryant had three hits, including his 27th homer, and Chicago overcame the ejections of John Lackey and Willson Contreras.

Bryant went deep in the fourth and singled twice in Chicago's seven-run sixth, helping the NL Central leaders open a big weekend series on a winning note.

The Cubs moved four games ahead of the Cardinals and stayed three ahead of Milwaukee, which defeated Miami on Friday night.

Lackey and Contreras were thrown out with Chicago trailing 2-1 in the fifth. But after outscoring the New York Mets 39-14 in a three-game sweep, the Cubs got enough big hits to improve to 9-4 against the Cardinals this year.

Tommy Pham homered for St. Louis. But the Cubs chased Carlos Martinez in the sixth, sending 11 batters to the plate and grabbing an 8-2 lead.

Lackey and Contreras were tossed after arguing with plate umpire Jordan Baker in the fifth.

Russell ready: Shortstop Addison Russell is just about ready to return to the Cubs' lineup.

The 2016 All-Star says he's pain-free and hopes to play this weekend against the Cardinals after being sidelined since Aug. 2 because of plantar fasciitis in his right foot. If not, he could be back early next week.

Tigers 3, White Sox 2: Mikie Mahtook hit a game-ending RBI single with two outs in the ninth inning to end Detroit's six-game skid.

Former Tigers reliever Al Alburquerque (0-2) walked Jeimer Candelario with one out in the ninth, and Aaron Bummer walked Tyler Collins with two outs. White Sox manager Rick Renteria brought in his third pitcher of the inning, Juan Minaya, who uncorked a wild pitch to move the runners to second and third.

Mahtook then hit a 3-2 pitch up the middle.

Red Sox fined: The Boston Red Sox have been fined by Major League Baseball for using electronic equipment to steal signs given by a Yankees catcher this season, and New York has been fined a lesser amount for improper use of a dugout telephone in an earlier year.

The discipline was announced Friday by baseball Commissioner Rob Manfred. The fine amounts were not announced. The money will be donated to hurricane relief efforts in Florida

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